HLA-DMB and DPM2

Number of citations of the paper that reports this interaction (PubMedID 11591653)
41

Data Source:
HPRD (in vivo)

		HLA-DMB	DPM2
Description		major histocompatibility complex, class II, DM beta	dolichyl-phosphate mannosyltransferase subunit 2, regulatory
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Enzyme Regulator Activity
	Biological Process	Adaptive Immune Response MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Regulation Of Catalytic Activity
Pathways		MHC class II antigen presentation	Synthesis of dolichyl-phosphate mannose Synthesis of glycosylphosphatidylinositol (GPI) Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Dermatomyositis ( 27153935) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Squamous cell lung carcinoma ( 28604730)	Body mass index ( 26426971) Glaucoma (primary angle closure) ( 27064256)
Interacting Genes		11 interacting genes: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 PSEN2 TEAD1	6 interacting genes: DPM1 DPM3 HLA-DMB PIGA PIGC VKORC1
Entrez ID		3109	8818
HPRD ID		00831	16028
Ensembl ID		ENSG00000242574	ENSG00000136908
Uniprot IDs		A0A1V0E3P2 P28068	O94777
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P
Enriched GO Terms of Interacting Partners?
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