SOCS7 and SORBS3

Number of citations of the paper that reports this interaction (PubMedID 15242778)
9

Data Source:
HPRD (two hybrid, in vivo)

		SOCS7	SORBS3
Description		suppressor of cytokine signaling 7	sorbin and SH3 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Protein Binding SH3 Domain Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Biological_process Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		Ovarian cancer ( 23535730)	Diastolic blood pressure ( 30224653) HIV-1 viral setpoint ( 20205591) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Parkinson's disease ( 28892059)
Interacting Genes		12 interacting genes: DAB1 EGFR GRB2 IRS2 IRS4 NCK1 PIK3R1 PIK3R2 PLCG1 SORBS3 TUBA1A TUBB4B	46 interacting genes: ABL1 ADAM15 ADAMTSL4 ARNT2 CBLB CPEB2 CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCK1 NCKIPSD NOTCH3 PAK2 PAK5 RBMX SAFB2 SAXO1 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		30837	10174
HPRD ID		12299	11535
Ensembl ID		ENSG00000274211	ENSG00000120896
Uniprot IDs		O14512	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?
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