HGFAC and SPINT2

Number of citations of the paper that reports this interaction (PubMedID 9346890)
37

Data Source:
HPRD (in vitro, in vivo)

		HGFAC	SPINT2
Description		HGF activator	serine peptidase inhibitor, Kunitz type 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Cytosol	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		MET Receptor Activation	MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163 31015462) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gamma glutamyl transferase levels ( 29403010) Height ( 31562340 29782485) Hepatocyte growth factor levels ( 27989323) Inflammatory bowel disease ( 26192919) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Platelet count ( 27863252) Plateletcrit ( 27863252) Pulse pressure ( 27841878 30578418) Serum total protein level ( 29403010) Triglyceride levels ( 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531)	Blood protein levels ( 30072576 29875488) Platelet count ( 27863252)
Interacting Genes		5 interacting genes: F2 HGF KLKB1 SPINT1 SPINT2	6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4
Entrez ID		3083	10653
HPRD ID		05184	05495
Ensembl ID		ENSG00000109758	ENSG00000167642
Uniprot IDs		D6RAR4 Q04756	A0A140VJV6 O43291
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U	4U32
Enriched GO Terms of Interacting Partners?
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