HCLS1 and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		HCLS1	LZTR1
Description		hematopoietic cell-specific Lyn substrate 1	leucine zipper like transcription regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Postsynaptic Density Lamellipodium Dendrite Site Of Polarized Growth Cortical Actin Cytoskeleton Postsynaptic Membrane	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding	DNA-binding Transcription Factor Activity Ras GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Cytokine Stimulus Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS
Interacting Genes		23 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MRAS MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		3059	8216
HPRD ID		03199	08992
Ensembl ID		ENSG00000180353	ENSG00000099949
Uniprot IDs		P14317	A0A384NL67 Q8N653
PDB IDs
Enriched GO Terms of Interacting Partners?
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