HCFC1 and E2F4

Number of citations of the paper that reports this interaction (PubMedID 17612494)
122

Data Source:
BioGRID (two hybrid)

		HCFC1	E2F4
Description		host cell factor C1	E2F transcription factor 4
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Membrane Axon Dendrite Protein-containing Complex Neuronal Cell Body Set1C/COMPASS Complex SAGA-type Complex MLL1 Complex	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Protein Binding, Bridging Activating Transcription Factor Binding Identical Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Cadherin Binding Histone Acetyltransferase Activity (H4-K16 Specific)	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Protein Dimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Remodeling Regulation Of Transcription, DNA-templated Mitochondrion Organization Cell Cycle Positive Regulation Of Gene Expression Protein Deubiquitination Release From Viral Latency Regulation Of Protein Complex Assembly Histone H4 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Protein Stabilization Cellular Response To Organic Cyclic Compound	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Epithelial Cell Development Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)
Interacting Genes		32 interacting genes: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIN3A SP1 TAF9 THAP11 THAP7 YY1 ZBTB17	29 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		3054	1874
HPRD ID		02061	02806
Ensembl ID		ENSG00000172534	ENSG00000205250
Uniprot IDs		A6NEM2 P51610	Q16254
PDB IDs		4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5	1CF7 5TUU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?