HADHA and ABCF2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HADHA	ABCF2
Description		hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	ATP binding cassette subfamily F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid	Membrane
	Molecular Function	Fatty-acyl-CoA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Acetyl-CoA C-acetyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity Protein-containing Complex Binding NAD Binding	ATP Binding ATPase Activity
	Biological Process	Fatty Acid Beta-oxidation Response To Insulin Cardiolipin Acyl-chain Remodeling Response To Drug
Pathways		Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Drugs		NADH
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP) Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Eyebrow thickness ( 26926045) Femoral neck bone mineral density ( 22504420) Height ( 31562340) IgG glycosylation ( 23382691) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		7 interacting genes: ABCF2 ATXN2L CD74 HSD17B10 NR4A1 PIN1 YWHAQ	2 interacting genes: HADHA UPF2
Entrez ID		3030	10061
HPRD ID		02934	12403
Ensembl ID		ENSG00000084754	ENSG00000033050
Uniprot IDs		E9KL44 P40939	A0A090N7X1 Q9UG63
PDB IDs		5ZQZ 5ZRV 6DV2
Enriched GO Terms of Interacting Partners?
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