HOOK2 and KANSL1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		HOOK2	KANSL1
Description		hook microtubule tethering protein 2	KAT8 regulatory NSL complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex Intracellular Membrane-bounded Organelle FHF Complex	Histone Acetyltransferase Complex Condensed Chromosome Kinetochore Nucleus Nucleoplasm NSL Complex MLL1 Complex
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding	Protein Binding Histone Acetyltransferase Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport	Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Monocyte count ( 27863252)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Automobile speeding propensity ( 30643258) Breast cancer ( 29059683) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive function ( 28093568) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General factor of neuroticism ( 30867560) Hand grip strength ( 29313844) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Male-pattern baldness ( 27182965 28196072) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neuroticism ( 29255261) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Parkinson's disease ( 31660654 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pulse pressure ( 27841878) Reaction time ( 29844566) Red blood cell count ( 29403010) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ventral diencephalon volume ( 31530798)
Interacting Genes		41 interacting genes: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 CCDC33 CWF19L2 DUSP13 EPS8 FAM107A HAUS1 HOOK1 HOOK3 IQCE ITSN2 KANSL1 KAT7 KIAA0408 KLK15 MCM10 PIMREG PSMF1 RALBP1 RIBC2 RITA1 RNF6 SMARCB1 SUV39H1 TPM3 TRMT1 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZNF250 ZNF638	35 interacting genes: CALCOCO2 CCDC136 CCDC85B CDC5L CDR2 CEP70 DISC1 DTNBP1 EXOC1 FSD2 GOLGA2 HOOK2 HSPB1 KAT8 KDM1A KIFC3 KRT15 MAGEA12 MDFI NECAB2 NINL NUP62 NUTM1 PLEKHA5 PNMA1 PSME3 RETREG3 SMAD3 SPAG5 TFIP11 TRAF2 TRAF4 TRIM27 USHBP1 WDR5
Entrez ID		29911	284058
HPRD ID		09698	11254
Ensembl ID		ENSG00000095066	ENSG00000120071
Uniprot IDs		Q96ED9	A0A024R9Y2 A0A1W2PRB5 Q7Z3B3
PDB IDs			4CY1 4CY2
Enriched GO Terms of Interacting Partners?
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