GUCY1A2 and DLG3

Number of citations of the paper that reports this interaction (PubMedID 11572861)
47

Data Source:
HPRD (in vitro)

		GUCY1A2	DLG3
Description		guanylate cyclase 1 soluble subunit alpha 2	discs large MAGUK scaffold protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Space Cytosol Plasma Membrane Bicellular Tight Junction Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction Growth Cone AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Protein-containing Complex Binding	Protein Binding Protein C-terminus Binding Kinase Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Structural Constituent Of Postsynaptic Density
	Biological Process	CGMP Biosynthetic Process Signal Transduction Positive Regulation Of Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction	MAPK Cascade Establishment Of Planar Polarity Negative Regulation Of Cell Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure Regulation Of NMDA Receptor Activity
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Nitric Oxide Isosorbide Mononitrate Riociguat Methylene blue Plecanatide
Diseases			Non-syndromic X-linked mental retardation
GWAS		Anxiety disorder ( 25390645) Colorectal or endometrial cancer ( 26621817) Diastolic blood pressure ( 27841878) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Upper eyelid morphology ( 29921221) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Whole brain grey matter density ( 31530798)
Interacting Genes		8 interacting genes: DLG1 DLG2 DLG3 DLG4 ERBIN GUCY1B1 SNTA1 STUB1	40 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1
Entrez ID		2977	1741
HPRD ID		03146	02177
Ensembl ID		ENSG00000152402	ENSG00000082458
Uniprot IDs		P33402	Q59FY1 Q92796
PDB IDs			1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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