CXCL2 and CXCR1

Number of citations of the paper that reports this interaction (PubMedID 9260277)
7

Data Source:
HPRD (in vivo, in vitro)

		CXCL2	CXCR1
Description		C-X-C motif chemokine ligand 2	C-X-C motif chemokine receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cell Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Dendritic Cell Chemotaxis Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Degranulation Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ketoprofen
Diseases
GWAS		Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 27863252) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 27863252 21738479) White blood cell types ( 21738478)	Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)
Interacting Genes		5 interacting genes: CXCR1 CXCR2 EPS8 PIK3R1 PLG	16 interacting genes: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C
Entrez ID		2920	3577
HPRD ID		00741	00908
Ensembl ID		ENSG00000081041	ENSG00000163464
Uniprot IDs		A0A024RDD9 P19875	P25024
PDB IDs		1QNK 5OB5	1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?
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