GRM2 and GNA15

Number of citations of the paper that reports this interaction (PubMedID 8863838)
15

Data Source:
HPRD (in vivo)

		GRM2	GNA15
Description		glutamate metabotropic receptor 2	G protein subunit alpha 15
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Presynaptic Membrane Integral Component Of Postsynaptic Membrane	Cell Heterotrimeric G-protein Complex Plasma Membrane Synapse
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		LY2140023
Diseases
GWAS			Glucose homeostasis traits ( 25524916) Heart failure ( 20445134)
Interacting Genes		9 interacting genes: GNA15 GNAQ GRIP1 LMNA NAALADL2 RGS12 SDCBP TAMALIN UBQLN1	19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		2912	2769
HPRD ID		04977	00760
Ensembl ID		ENSG00000164082	ENSG00000060558
Uniprot IDs		Q14416	P30679
PDB IDs		4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
Enriched GO Terms of Interacting Partners?
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