DROSHA and DGCR8

Number of citations of the paper that reports this interaction (PubMedID 15574589)
670

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DROSHA	DGCR8
Description		drosha ribonuclease III	DGCR8 microprocessor complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Postsynaptic Density Microprocessor Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Microprocessor Complex
	Molecular Function	Lipopolysaccharide Binding RNA Binding Double-stranded RNA Binding Ribonuclease III Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding R-SMAD Binding Primary MiRNA Binding	Double-stranded RNA Binding Ribonuclease III Activity Protein Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Primary MiRNA Binding
	Biological Process	RNA Processing MiRNA Metabolic Process Positive Regulation Of Gene Expression RRNA Catabolic Process Production Of SiRNA Involved In RNA Interference Primary MiRNA Processing Pre-miRNA Processing Ribosome Biogenesis Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of MiRNA Metabolic Process	MiRNA Metabolic Process Primary MiRNA Processing RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		MicroRNA (miRNA) biogenesis	MicroRNA (miRNA) biogenesis Transcriptional Regulation by MECP2
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Lung function (FEV1) ( 26635082) Tuberculosis ( 30713548)	Metabolite levels ( 23823483) Serum metabolite levels ( 23093944)
Interacting Genes		3 interacting genes: DGCR8 SP1 ZNF512B	3 interacting genes: APP DROSHA MEOX2
Entrez ID		29102	54487
HPRD ID		10196	09913
Ensembl ID		ENSG00000113360	ENSG00000128191
Uniprot IDs		Q9NRR4	Q8WYQ5
PDB IDs		2KHX 2NA2 5B16	1X47 2YT4 3LE4 5B16
Enriched GO Terms of Interacting Partners?
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