CCDC22 and ACTG1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CCDC22	ACTG1
Description		coiled-coil domain containing 22	actin gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cell Nucleoplasm Endosome Cytosol	Extracellular Space Nucleus Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Myofibril Filamentous Actin Apical Junction Complex Calyx Of Held Phagocytic Vesicle Extracellular Exosome Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Binding Cullin Family Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Profilin Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Cellular Copper Ion Homeostasis Golgi To Plasma Membrane Transport Cytoplasmic Sequestering Of NF-kappaB Protein Transport Protein Ubiquitination Endocytic Recycling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Post-translational Protein Modification Retrograde Transport, Endosome To Plasma Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Angiogenesis Morphogenesis Of A Polarized Epithelium Retina Homeostasis Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Cell Junction Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Sarcomere Organization Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Membrane Organization Platelet Aggregation Cellular Response To Interferon-gamma Positive Regulation Of Wound Healing Postsynaptic Actin Cytoskeleton Organization Tight Junction Assembly Protein Localization To Bicellular Tight Junction
Pathways		Neddylation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			Copper Artenimol
Diseases
GWAS		Vitiligo ( 27723757)	Hand grip strength ( 29313844)
Interacting Genes		5 interacting genes: ACTG1 BLOC1S6 CPNE1 CPNE4 USHBP1	65 interacting genes: ABLIM1 ACTB ANXA5 ATF7IP BCAP31 BIN1 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK HRAS HSPB2 LGALS13 LIG4 LSP1 MAP1A MAPK6 MAPT MCPH1 MYO1A MYOC NDRG1 NR3C2 NTAQ1 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 SRPK2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WIPF1
Entrez ID		28952	71
HPRD ID		06594	00017
Ensembl ID		ENSG00000101997	ENSG00000184009
Uniprot IDs		A0A024QZ03 O60826	P63261
PDB IDs			5JLH 6CXI 6CXJ 6G2T
Enriched GO Terms of Interacting Partners?
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