RAPGEF1 and RAP1B

Number of citations of the paper that reports this interaction (PubMedID 8524240)
78

Data Source:
HPRD (in vivo, in vitro)

		RAPGEF1	RAP1B
Description		Rap guanine nucleotide exchange factor 1	RAP1B, member of RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Phagocytic Vesicle Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Intracellular Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Rap Guanyl-nucleotide Exchange Factor Activity SH3 Domain Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Neuron Projection Development Cytokine-mediated Signaling Pathway Rap Protein Signal Transduction Nerve Growth Factor Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity Cell-cell Adhesion Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Cell Proliferation Response To Carbohydrate Microvillus Assembly Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Cellular Response To Drug Interleukin-12-mediated Signaling Pathway Neutrophil Degranulation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Gonadotropin-releasing Hormone Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Cerebrospinal fluid Î±-synuclein levels ( 29959729) Optic disc size ( 31809533)	White blood cell count ( 20139978)
Interacting Genes		19 interacting genes: ABL1 ATXN1 BCAR1 CRK CRKL EGFR GRB2 HCK HRAS MBIP NEDD9 RAP1A RAP1B RAP2B RHOQ RPS15 RRAS2 SHC1 SLC20A1	29 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		2889	5908
HPRD ID		02627	01546
Ensembl ID		ENSG00000107263	ENSG00000127314
Uniprot IDs		Q13905	A0A024RB87 B7ZAY2 P61224
PDB IDs		5L23	3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6
Enriched GO Terms of Interacting Partners?
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