KCTD1 and POLR1C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KCTD1	POLR1C
Description		potassium channel tetramerization domain containing 1	RNA polymerase I and III subunit C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Centriolar Satellite Intercellular Bridge	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization	Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Gene Expression, Epigenetic
Pathways		Negative regulation of activity of TFAP2 (AP-2) family transcription factors	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		Estimated glomerular filtration rate ( 31015462) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Sudden cardiac arrest ( 21658281)	GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: EPM2AIP1 EXOSC1 KCTD15 LMO3 LNX1 NTAQ1 POLR1C PRKAA2 PSMA1 SDCBP TRAPPC2B UBE2I ZBTB25	35 interacting genes: ATRIP BIRC7 CBY2 CCDC33 CD3EAP CLU CORO1A CORO1B IHO1 IKZF3 KCTD1 KRT19 LNX2 LZTS2 MBIP MKRN3 MYD88 MYO5B NFKBIB NME1 POLR1D POLR1E PPP2R3C RIMBP3 SAXO1 SMN2 TASOR2 TCF4 TFIP11 TNFAIP1 TRIM27 TRIOBP TSC22D4 VIM WRN
Entrez ID		284252	9533
HPRD ID		11059	09661
Ensembl ID		ENSG00000134504	ENSG00000171453
Uniprot IDs		A0A024RC45 A0A2U3U043 Q719H9	O15160
PDB IDs		5BXB 5BXD
Enriched GO Terms of Interacting Partners?
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