GPM6B and CLN8

Number of citations of the paper that reports this interaction (PubMedID 23142642)
4

Data Source:
BioGRID (two hybrid)

		GPM6B	CLN8
Description		glycoprotein M6B	CLN8 transmembrane ER and ERGIC protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Membrane Raft	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Molecular_function	Protein Binding Ceramide Binding
	Biological Process	Ossification Nervous System Development Protein Transport Positive Regulation Of Bone Mineralization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Serotonin Uptake Regulation Of Focal Adhesion Assembly Extracellular Matrix Assembly Negative Regulation Of Protein Localization To Cell Surface	Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Nervous System Development Cholesterol Metabolic Process Lipid Biosynthetic Process Protein Catabolic Process Negative Regulation Of Proteolysis Ceramide Biosynthetic Process
Pathways
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Delayed reward discounting ( 29230059)	Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		3 interacting genes: CLN8 EGFR MTNR1B	29 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1
Entrez ID		2824	2055
HPRD ID		02082	06383
Ensembl ID		ENSG00000046653	ENSG00000182372
Uniprot IDs		A0A024RBV7 A0A024RBX1 Q13491 Q59FD5	A0A024QZ57 Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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