MAT2B and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAT2B	KPNA4
Description		methionine adenosyltransferase 2B	karyopherin subunit alpha 4
Image
GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Nuclear Pore Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Regulation Of Catalytic Activity	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Response To Hydrogen Peroxide
Pathways		Methylation Ub-specific processing proteases	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		12 interacting genes: APP CNIH4 FBXO25 GABRA1 KPNA3 KPNA4 MAT2A MSX2 STC1 TMED9 TRIM27 YTHDF3	20 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 GTF2IRD1 HIF1A HNRNPC KPNB1 MAT2B NTRK3 PLAA RAC1 RCC1 RECQL TGM2 TP53 WT1
Entrez ID		27430	3840
HPRD ID		05701	04275
Ensembl ID		ENSG00000038274	ENSG00000186432
Uniprot IDs		A0A140VJP2 Q9NZL9	O00629
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB
Enriched GO Terms of Interacting Partners?
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