GLP1R and SAA1

Number of citations of the paper that reports this interaction (PubMedID 28597972)
0

Data Source:
BioGRID (protein complementation assay)

		GLP1R	SAA1
Description		glucagon like peptide 1 receptor	serum amyloid A1
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cell Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Glucagon-like Peptide 1 Receptor Activity	G Protein-coupled Receptor Binding Heparin Binding Chemoattractant Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus Response To Psychosocial Stress	Activation Of MAPK Activity Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response Positive Chemotaxis Cell Chemotaxis
Pathways		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation
Drugs		Glucagon recombinant Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide	Human Serum Albumin
Diseases
GWAS		Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282)	Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)
Interacting Genes		106 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 C4orf3 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 LAPTM4A LINC00269 MFSD5 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMCO3 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99	10 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R GNG5 LAMA1 SELENOS VKORC1
Entrez ID		2740	6288
HPRD ID		00677	00097
Ensembl ID		ENSG00000112164	ENSG00000173432
Uniprot IDs		A0A142FHB8 P43220	P0DJI8
PDB IDs		3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1	4IP8 4IP9 6MST
Enriched GO Terms of Interacting Partners?
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