CACYBP and PINX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CACYBP	PINX1
Description		calcyclin binding protein	PIN2 (TERF1) interacting telomerase inhibitor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Beta-catenin Destruction Complex Neuron Projection Cell Body Extracellular Exosome	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Cell Nucleoplasm Nucleolus Spindle
	Molecular Function	Protein Binding Tubulin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity S100 Protein Binding	Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Heart Development Aging Positive Regulation Of DNA Replication Cardiac Muscle Cell Differentiation Response To Growth Hormone Negative Regulation Of Cell Death Cellular Response To Calcium Ion Cellular Response To Leukemia Inhibitory Factor	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus
Pathways
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Autism spectrum disorder ( 30804558) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte counts ( 27863252) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899) Triglycerides ( 24097068 30275531 20686565) Type 2 diabetes ( 30054458) White blood cell count ( 27863252)
Interacting Genes		18 interacting genes: BEX3 CD8A EDEM3 FBXO7 HSP90AA1 HSP90B1 MAPK1 PEA15 PINX1 PRKCA S100A1 S100A12 S100A6 S100B S100P SIAH1 SIAH2 SKP1	10 interacting genes: AIDA APP CACYBP GABPA MCRS1 MPZ PAFAH1B2 TERF1 TERT TP63
Entrez ID		27101	54984
HPRD ID		07316	05934
Ensembl ID		ENSG00000116161	ENSG00000254093
Uniprot IDs		A0A024R904 Q9HB71	Q96BK5
PDB IDs		1X5M 2A25 2A26
Enriched GO Terms of Interacting Partners?
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