USP21 and USP33

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		USP21	USP33
Description		ubiquitin specific peptidase 21	ubiquitin specific peptidase 33
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Focal Adhesion VCB Complex Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ral GTPase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated	Ubiquitin-dependent Protein Catabolic Process Endocytosis Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Autophagy Cell Migration Protein Deubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Ub-specific processing proteases Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS			Post bronchodilator FEV1 ( 26634245)
Interacting Genes		54 interacting genes: ATXN3 AURKA BAP1 BRCA2 CBL CBLC DTX3 ESPL1 EXOSC10 FOXM1 H2AC18 ISG15 JOSD1 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350	14 interacting genes: CCP110 DDX56 DIO2 EIF6 ELOB ELOC SELENBP1 TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL
Entrez ID		27005	23032
HPRD ID		05291	10297
Ensembl ID		ENSG00000143258	ENSG00000077254
Uniprot IDs		Q9UK80	Q8TEY7
PDB IDs		2Y5B 3I3T 3MTN	2UZG
Enriched GO Terms of Interacting Partners?
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