GJA1 and PRKCA

Number of citations of the paper that reports this interaction (PubMedID 10871288)
154

Data Source:
HPRD (in vitro, in vivo)

		GJA1	PRKCA
Description		gap junction protein alpha 1	protein kinase C alpha
Image
GO Annotations	Cellular Component	Golgi Membrane Cell Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexin Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Cell Junction Golgi-associated Vesicle Membrane Intracellular Membrane-bounded Organelle Cell-cell Contact Zone Membrane Raft Tight Junction	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Mitochondrial Membrane Alphav-beta3 Integrin-PKCalpha Complex Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Gap Junction Channel Activity Protein Binding Beta-catenin Binding Ion Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Tubulin Binding SH3 Domain Binding PDZ Domain Binding Glutathione Transmembrane Transporter Activity Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Disordered Domain Specific Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)
	Biological Process	Establishment Of Mitotic Spindle Orientation Negative Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Response To Ischemia Positive Regulation Of Glomerular Filtration Endothelium Development Apoptotic Process Muscle Contraction Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Spermatogenesis Heart Development Response To PH Response To Glucose Vascular Transport Cell Communication By Electrical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Glutamate Secretion ATP Transport Gap Junction Assembly Regulation Of Transmembrane Transporter Activity Negative Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Negative Regulation Of Gonadotropin Secretion Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Ion Transmembrane Transport Response To Fluid Shear Stress Cellular Protein Localization Glutathione Transmembrane Transport Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Peptide Hormone Positive Regulation Of Protein Catabolic Process Positive Regulation Of Vasoconstriction Decidualization Bone Remodeling Neuron Projection Morphogenesis Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Cellular Response To Parathyroid Hormone Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Blood Vessel Diameter Positive Regulation Of Cold-induced Thermogenesis Export Across Plasma Membrane Negative Regulation Of Trophoblast Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Mesodermal Cell Differentiation Epididymis Development Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Stem Cell Proliferation Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Behavioral Fear Response	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Regulation Of Insulin Secretion Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis
Pathways		Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction assembly Gap junction degradation Regulation of gap junction activity Regulation of gap junction activity Formation of annular gap junctions	Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerisation of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs		Carvedilol	Phosphatidyl serine Vitamin E Tamoxifen Ingenol Mebutate Midostaurin Ellagic Acid
Diseases		Syndactyly Deafness, autosomal recessive Oculodentodigital dysplasia
GWAS		Atrial fibrillation ( 28416818 28416822 29892015) Disease progression in age-related macular degeneration ( 29346644) Focal epilepsy (with hippocampal sclerosis) ( 30531953) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heel bone mineral density ( 30598549) Migraine ( 27322543) Peak creatinine levels in vancomycin therapy ( 26030142) Protein quantitative trait loci ( 18464913) Pulse pressure ( 28135244 27841878) Resting heart rate ( 29769521 23183192 27798624 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Tendinopathy ( 31615970) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Coronary artery calcification ( 23870195) Feeling guilty ( 29500382) Food addiction ( 27106561) Gout ( 22179738) Height ( 22021425) Heschl's gyrus morphology ( 25130324) Lateral occipital cortex volume ( 31530798) Neuroticism ( 29255261) Percent glycated albumin ( 29844224) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) QRS complex (12-leadsum) ( 27659466) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 30012220 27659466) QT interval ( 29213071 24952745) Systolic blood pressure ( 31170924) Total glycated albumin levels ( 29844224)
Interacting Genes		21 interacting genes: AKT1 CAV1 CCN3 CNST CREB3 CSK CSNK1D GJA3 GJA5 MAPK1 MAPK3 MAPK7 PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1 UBQLN4	229 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKACA PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SLC9A3R1 SLC9A3R2 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ
Entrez ID		2697	5578
HPRD ID		00414	01498
Ensembl ID		ENSG00000152661	ENSG00000154229
Uniprot IDs		P17302	L7RSM7 P17252 Q7Z727
PDB IDs		2LL2	2ELI 3IW4 4DNL 4RA4
Enriched GO Terms of Interacting Partners?
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