NUPR1 and SET

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NUPR1	SET
Description		nuclear protein 1, transcriptional regulator	SET nuclear proto-oncogene
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein-DNA Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Acetyltransferase Activator Activity	DNA Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding
	Biological Process	Acute Inflammatory Response Protein Acetylation Negative Regulation Of Cell Proliferation Male Gonad Development Response To Toxic Substance Regulation Of Autophagy Negative Regulation Of Autophagy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Protein Modification Process Skeletal Muscle Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Glycolytic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Autophagosome Assembly Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Oxidative Phosphorylation Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Female Gonad Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	DNA Replication Nucleosome Assembly Nucleosome Disassembly Viral Process Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Histone Acetylation Regulation Of MRNA Stability Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Crohn's disease ( 28067908) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Offspring birth weight ( 31043758) Urinary metabolite levels in chronic kidney disease ( 31959995)	Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		21 interacting genes: ABCG8 ALDH1A1 EP300 FUS KNSTRN MAPRE1 MPHOSPH6 MSL1 NACA NONO NPY5R PAXIP1 PSMD4 PTMA RAN RANBP1 RPL41 SEC11A SET STX18 SYNCRIP	54 interacting genes: ANP32A APEX1 APP CALM1 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H2BC1 H3-3A H3-4 H4-16 H4C14 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PIK3CG PPP2CA PPP2R1B PRKAR1A PTMA RAC1 SDCBP SETBP1 SGO1 TAF1A TERF1 TERF2 TERF2IP THAP7 TREX1 UCHL5 XRCC6
Entrez ID		26471	6418
HPRD ID		17814	09023
Ensembl ID		ENSG00000176046	ENSG00000119335
Uniprot IDs		A0A024QZC4 O60356	A0A024R895 A0A0C4DFV9 Q01105 Q5VXV3
PDB IDs			2E50
Enriched GO Terms of Interacting Partners?
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