FBXO4 and FXR1

Number of citations of the paper that reports this interaction (PubMedID 29142209)
9

Data Source:
BioGRID (enzymatic study)

		FBXO4	FXR1
Description		F-box protein 4	FMR1 autosomal homolog 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cell Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleolus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Axon Growth Cone Ribonucleoprotein Granule Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Costamere Dendritic Spine Dendritic Spine Neck Perinuclear Region Of Cytoplasm Presynapse Glutamatergic Synapse Dendritic Filopodium
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding RNA Strand Annealing Activity Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Aging Posttranscriptional Regulation Of Gene Expression Protein Ubiquitination Cellular Homeostasis SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Telomere Maintenance Via Telomerase Common Myeloid Progenitor Cell Proliferation Post-translational Protein Modification Negative Regulation Of Fibroblast Proliferation Cellular Response To Ionizing Radiation Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Polyubiquitination Regulation Of DNA Damage Checkpoint	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Apoptotic Process Muscle Organ Development Negative Regulation Of Translation Cell Differentiation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Positive Regulation Of Gene Silencing By MiRNA Positive Regulation Of Response To DNA Damage Stimulus
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Signaling by BRAF and RAF fusions
Drugs
Diseases
GWAS			Bipolar disorder and eating disorder ( 26433762) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eating disorder in bipolar disorder ( 26433762) Metabolite levels ( 23823483) Schizophrenia ( 25056061 19571811 29483656 30285260)
Interacting Genes		7 interacting genes: CCND1 CDC34 ELF4 FXR1 SKP1 TERF1 UBE2D2	13 interacting genes: CEP126 CRMP1 CSNK2A1 CYFIP2 ERG28 FBXO4 FMR1 FXR2 GBP2 HSPB1 LRIF1 LUC7L2 PRSS23
Entrez ID		26272	8087
HPRD ID		09949	02892
Ensembl ID		ENSG00000151876	ENSG00000114416
Uniprot IDs		B3KNA0 D6RAJ6 Q9UKT5	A0A0F7KYT8 A0A0F7L1S3 P51114
PDB IDs		3L2O 3L82	2CPQ 3KUF 3O8V
Enriched GO Terms of Interacting Partners?
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