NECAP1 and HIP1

Number of citations of the paper that reports this interaction (PubMedID 17762867)
14

Data Source:
HPRD (in vivo)

		NECAP1	HIP1
Description		NECAP endocytosis associated 1	huntingtin interacting protein 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Membrane Clathrin-coated Vesicle Actin Cortical Patch Clathrin-coated Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Presynapse Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function		Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Endocytosis Protein Transport Vesicle-mediated Transport Membrane Organization	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Protein Kinase B Signaling Membrane Organization Clathrin-dependent Endocytosis Apoptotic Signaling Pathway Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		8 interacting genes: AMPH APP DAB2 DAPK1 DNAJC5 HIP1 REL SNAP91	25 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CLTA CLTB CLTC DAZAP2 DVL2 EIF6 FBXO25 HIP1R HTT IFT57 ITSN1 MAP3K1 MAPK6 NECAP1 PFDN1 REL RPS10 SMURF1 TFAP2A
Entrez ID		25977	3092
HPRD ID		14819	03461
Ensembl ID		ENSG00000089818	ENSG00000127946
Uniprot IDs		Q8NC96	B4DK46 O00291
PDB IDs		6RH5 6RH6	2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?
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