WWTR1 and PAX3

Number of citations of the paper that reports this interaction (PubMedID 16300735)
38

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		WWTR1	PAX3
Description		WW domain containing transcription regulator 1	paired box 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Body	Nuclear Chromatin Nucleoplasm
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Negative Regulation Of Protein Phosphorylation Heart Process Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly Regulation Of SMAD Protein Signal Transduction Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway	Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Muscle Organ Development Sensory Perception Of Sound Animal Organ Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	HATs acetylate histones
Drugs
Diseases			Alveolar rhabdomyosarcoma Craniofacial-deafness-hand syndrome Waardenburg syndrome (WS)
GWAS		Height ( 31562340) Preeclampsia ( 23551011)	Adolescent idiopathic scoliosis ( 26394188) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132) Facial morphology ( 31763980 22341974) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Information processing speed ( 25869804) Male-pattern baldness ( 28196072) middle facial morphology traits (quantitative measurement) ( 27193062) Monobrow ( 27182965) Monobrow thickness ( 26926045) Nose size ( 27182965) Vitamin D levels ( 25208829)
Interacting Genes		17 interacting genes: DAPK1 LATS1 LATS2 MFHAS1 NKX2-1 PAX3 PLOD2 PPP1CA RUNX1 SLC9A3R2 SUMO3 TEAD3 TEAD4 WBP2 YWHAE YWHAG YWHAZ	16 interacting genes: CIB1 DAXX FZR1 HDAC10 IPO13 MEOX1 MEOX2 MITF MSX1 POU3F2 RAD23B SOX10 SOX8 TAF1 TBP WWTR1
Entrez ID		25937	5077
HPRD ID		09580	09421
Ensembl ID		ENSG00000018408	ENSG00000135903
Uniprot IDs		Q9GZV5	P23760
PDB IDs		5N5R 5N5T 5N5W 5N75	3CMY
Enriched GO Terms of Interacting Partners?
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