SOSTDC1 and BMP6

Number of citations of the paper that reports this interaction (PubMedID 14623234)
75

Data Source:
HPRD (in vitro)

		SOSTDC1	BMP6
Description		sclerostin domain containing 1	bone morphogenetic protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Space Cell Cytoplasm Vesicle
	Molecular Function	BMP Binding BMP Receptor Activity	Cytokine Activity Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Pattern Specification Process Negative Regulation Of Cell Fate Commitment Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Myoblast Differentiation Mammary Gland Bud Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Determination Of Dorsal Identity	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Response To Glucocorticoid Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Multicellular Organismal Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion
Pathways
Drugs
Diseases
GWAS		Response to statin therapy ( 20339536)	Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Pulse pressure ( 27841878 30578418) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730)
Interacting Genes		5 interacting genes: BMP2 BMP4 BMP6 BMP7 CDC20	11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1 TDGF1
Entrez ID		25928	654
HPRD ID		15417	00211
Ensembl ID		ENSG00000171243	ENSG00000153162
Uniprot IDs		A4D125 Q6X4U4	B4DUF7 P22004 Q4VBA3
PDB IDs			2QCW 2R52 2R53 6OMO
Enriched GO Terms of Interacting Partners?
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