SHC2 and NTRK2

Number of citations of the paper that reports this interaction (PubMedID 9507002)
22

Data Source:
HPRD (in vivo)

		SHC2	NTRK2
Description		SHC adaptor protein 2	neurotrophic receptor tyrosine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Golgi Membrane Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Cell Junction Axon Dendrite Early Endosome Membrane Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway	Vasculogenesis Neuron Migration Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Multicellular Organism Development Nervous System Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Mechanoreceptor Differentiation Regulation Of GTPase Activity Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Synapse Assembly Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis
Pathways		Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade	NGF-independant TRKA activation BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs			Amitriptyline
Diseases			Neuroblastoma
GWAS		Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Birth weight ( 24950379) Body mass index ( 28892062 25760438) Lifetime anxiety disorder ( 31748690) Menarche (age at onset) ( 25231870) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31118516) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594)
Interacting Genes		8 interacting genes: ERBB2 FLT1 GRB2 KDR NTRK1 NTRK2 NTRK3 RPL36	33 interacting genes: AP1B1 BDNF DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		25759	4915
HPRD ID		19296	02712
Ensembl ID		ENSG00000129946	ENSG00000148053
Uniprot IDs		P98077	A0A024R230 Q16620 Q548C2 Q5VWE5
PDB IDs			1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9
Enriched GO Terms of Interacting Partners?
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