NEIL2 and MEOX1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NEIL2	MEOX1
Description		nei like DNA glycosylase 2	mesenchyme homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Spindle Microtubule Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Molecular_function Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding
	Biological Process	Base-excision Repair Nucleotide-excision Repair Depyrimidination	Somite Specification Multicellular Organism Development Biological_process Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Somite Development Sclerotome Development
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs		Iron Copper
Diseases
GWAS		Alcohol dependence ( 23942779) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Fractures ( 30158200)
Interacting Genes		4 interacting genes: EP300 MEOX1 REL TRIM27	33 interacting genes: ACBD4 ALOX5 APP APPL1 BANP CIAO1 CIB3 CKS1B CWF19L2 CYFIP1 DCX FMR1 LMNA MAPK9 MEF2A MID1 MORF4L1 MVP NAGK NEIL2 PAGE3 PAX1 PAX3 PRKN QRICH1 RANBP3 RBM5 SOX10 SYT17 TCEANC TXLNA UBE2R2 UBXN2B
Entrez ID		252969	4222
HPRD ID		16406	02537
Ensembl ID		ENSG00000154328	ENSG00000005102
Uniprot IDs		A0A024R361 Q969S2	P50221
PDB IDs		1VZP
Enriched GO Terms of Interacting Partners?
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