STX12 and SNAP25

Number of citations of the paper that reports this interaction (PubMedID 10886332)
25

Data Source:
HPRD (in vivo)

		STX12	SNAP25
Description		syntaxin 12	synaptosome associated protein 25
Image
GO Annotations	Cellular Component	Golgi Membrane Phagophore Assembly Site Synaptic Vesicle Endomembrane System Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane BLOC-1 Complex SNARE Complex Early Endosome Membrane Vesicle Membrane Raft Phagocytic Vesicle Recycling Endosome Membrane Postsynaptic Recycling Endosome	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Vesicle Fusion Cholesterol Efflux Vesicle Docking Protein Stabilization	Neurotransmitter Uptake Exocytosis Vesicle Fusion Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Neutrophil Degranulation Regulation Of Insulin Secretion Long-term Synaptic Potentiation Potassium Ion Transmembrane Transport Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Neurotransmitter Receptor Internalization
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (BoNT/A) Toxicity of botulinum toxin type C (BoNT/C) Toxicity of botulinum toxin type E (BoNT/E) Neutrophil degranulation GABA synthesis, release, reuptake and degradation
Drugs			Botulinum Toxin Type A
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		12 interacting genes: BLOC1S6 DNAJC5 DTX2 EEA1 EPB42 HOMER1 LMNA NAPA NSG1 SNAP23 SNAP25 SNAP29	35 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17
Entrez ID		23673	6616
HPRD ID		06059	02637
Ensembl ID		ENSG00000117758	ENSG00000132639
Uniprot IDs		Q86Y82	P60880
PDB IDs		2DNX	1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J
Enriched GO Terms of Interacting Partners?
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