RBFOX2 and NR2E3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		RBFOX2	NR2E3
Description		RNA binding fox-1 homolog 2	nuclear receptor subfamily 2 group E member 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Transcription Factor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Definitive Erythrocyte Differentiation RNA Metabolic Process Radial Glia Guided Migration Of Purkinje Cell Intracellular Estrogen Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Dendrite Morphogenesis Neuromuscular Process Controlling Balance	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Visual Perception Phototransduction Negative Regulation Of Cell Proliferation Cell Differentiation Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Rhodopsin Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Retina Development In Camera-type Eye
Pathways		FGFR2 alternative splicing
Drugs
Diseases			Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Retinitis pigmentosa (RP)
GWAS		Reading disability or specific language impairment (pleiotropy) ( 25065397) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		53 interacting genes: APH1A ATN1 ATXN1 ATXN1L BOLL BRD7 C1orf94 CAMK2B CHAF1A CLASP2 DAB1 DAZAP2 DDX5 DEDD2 DMRTB1 ELAVL1 ELAVL2 ESR1 ESR2 GLIS2 GTF2A1L HNRNPAB HNRNPF HNRNPH2 HNRNPK KHDRBS1 MAGED1 MAPK1IP1L MED7 NAF1 NR2E3 PCBP1 POLR3D PSMA3 PSMF1 PTBP1 QKI RBFOX1 RBM22 RBM23 RBM42 RBPMS RERE RHOXF2 RNF8 SF3A1 SMN1 SNRPC SPOP TOLLIP U2AF2 VAC14 ZNF137P	28 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 ZNF232
Entrez ID		23543	10002
HPRD ID		15231	05132
Ensembl ID		ENSG00000100320	ENSG00000278570
Uniprot IDs		O43251	F1D8Q9 Q9Y5X4
PDB IDs		2CQ3	4LOG
Enriched GO Terms of Interacting Partners?
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