FOS and GRHPR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FOS	GRHPR
Description		Fos proto-oncogene, AP-1 transcription factor subunit	glyoxylate and hydroxypyruvate reductase
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Cytosol Membrane Protein-DNA Complex Transcription Factor AP-1 Complex Neuron Projection	Cytoplasm Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding R-SMAD Binding	Glycerate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Hydroxypyruvate Reductase Activity Glyoxylate Reductase (NADP) Activity Carboxylic Acid Binding Protein Homodimerization Activity NAD Binding NADPH Binding
	Biological Process	Conditioned Taste Aversion DNA Methylation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Light Stimulus Response To Gravity Response To Toxic Substance Cytokine-mediated Signaling Pathway Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Cellular Response To Reactive Oxygen Species Response To Immobilization Stress Skeletal Muscle Cell Differentiation Response To Muscle Stretch Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Positive Regulation Of Neuron Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Excretion Cellular Nitrogen Compound Metabolic Process Dicarboxylic Acid Metabolic Process Glyoxylate Metabolic Process Oxidation-reduction Process
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Glyoxylate metabolism and glycine degradation
Drugs		Pseudoephedrine Nadroparin
Diseases			Primary hyperoxaluria (HP)
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)	Bipolar disorder ( 31043756) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)
Interacting Genes		114 interacting genes: ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5ME BATF BCL3 CABP1 CARM1 CCND1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 DNMT3L EEF1D ELK1 ELK4 EPHB2 ETS1 ETS2 FHL3 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HNF1A HSPA1A JUN JUNB JUND KDM2A KDM2B LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK3 MAPK7 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PIN1 PML POLR2E PRKAA2 PRKACA PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133	6 interacting genes: CDC7 FOS GLS2 LIG4 LSM1 PTH2R
Entrez ID		2353	9380
HPRD ID		01275	05052
Ensembl ID		ENSG00000170345	ENSG00000137106
Uniprot IDs		P01100 Q6FG41	A0A384N605 Q9UBQ7
PDB IDs		1A02 1FOS 1S9K	2GCG 2H1S 2Q50 2WWR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?