SUZ12 and PJA1

Number of citations of the paper that reports this interaction (PubMedID 21513699)
20

Data Source:
BioGRID (enzymatic study)

		SUZ12	PJA1
Description		SUZ12 polycomb repressive complex 2 subunit	praja ring finger ubiquitin ligase 1
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GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex	Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific) Promoter-specific Chromatin Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Histone Ubiquitination Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Oligodendrocyte Differentiation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation	Protein Ubiquitination Protein Catabolic Process
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	Birth weight ( 31043758) Body mass index ( 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		23512	64219
HPRD ID		06949	02335
Ensembl ID		ENSG00000178691	ENSG00000181191
Uniprot IDs		J3QQW9 Q15022	Q8NG27
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24	2L0B
Enriched GO Terms of Interacting Partners?
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