ZFPM2 and GATA3

Number of citations of the paper that reports this interaction (PubMedID 14985365)
42

Data Source:
HPRD (two hybrid, in vitro)

		ZFPM2	GATA3
Description		zinc finger protein, FOG family member 2	GATA binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Interleukin-2 Receptor Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Transcription Regulatory Region DNA Binding E-box Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Gonadal Mesoderm Development Heart Development Blood Coagulation Cell Differentiation Lung Development Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Neuron Migration Type IV Hypersensitivity Kidney Development Mesonephros Development Lens Development In Camera-type Eye Immune System Development Pro-T Cell Differentiation Aortic Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Chromatin Remodeling Transcription By RNA Polymerase II Defense Response Humoral Immune Response Signal Transduction Axon Guidance Blood Coagulation Negative Regulation Of Cell Proliferation Male Gonad Development Response To Virus Anatomical Structure Morphogenesis Post-embryonic Development Positive Regulation Of Signal Transduction Response To Gamma Radiation Positive Regulation Of Endothelial Cell Migration Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Cytokine-mediated Signaling Pathway Erythrocyte Differentiation Regulation Of Epithelial Cell Differentiation TOR Signaling Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Hemopoiesis Cellular Response To Interferon-alpha Ureter Maturation Parathyroid Hormone Secretion Regulation Of Cytokine Biosynthetic Process Norepinephrine Biosynthetic Process Inner Ear Morphogenesis Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Neuron Apoptotic Process Ear Development Response To Estrogen Thymic T Cell Selection T-helper 2 Cell Differentiation Innate Immune Response Cell Fate Commitment Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Thymus Development Embryonic Organ Development Developmental Growth Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Pharyngeal System Development Uterus Development Mesenchymal To Epithelial Transition Mast Cell Differentiation Ureteric Bud Formation Regulation Of Histone H3-K27 Methylation Canonical Wnt Signaling Pathway Involved In Metanephric Kidney Development Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Histone H3-K14 Acetylation Otic Vesicle Development Cellular Response To BMP Stimulus Positive Regulation Of Ureteric Bud Formation Nephric Duct Morphogenesis Nephric Duct Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Ureter Morphogenesis Interleukin-4 Secretion Interferon-gamma Secretion Lymphocyte Migration Cochlea Development Negative Regulation Of DNA Demethylation Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Establishment Of Cell Polarity Negative Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Cellular Response To X-ray Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
Pathways		Factors involved in megakaryocyte development and platelet production	Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Tetralogy of Fallot
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758) Blood protein levels ( 29875488 28240269) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Glaucoma (primary open-angle) ( 22570617) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 26805783 22139419 29403010 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) PR interval ( 30046033) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 26910538 21757650) Venous thromboembolism ( 25772935 28373160 31420334 31676865) White blood cell count (basophil) ( 27863252)	Acute lymphoblastic leukemia (adolescents and young adults) ( 25468567) Acute lymphoblastic leukemia (B-cell precursor) ( 29296818 23996088) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 27182965 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) B cell acute lymphoblastic leukaemia (abnormal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (hyperdiploid negative) ( 29296818) B cell acute lymphoblastic leukaemia (normal cytogenetics) ( 29296818) B cell acute lymphoblastic leukaemia (Philadelphia chromosome negative) ( 29296818) B cell acute lymphoblastic leukaemia in adulthood ( 29296818) B cell acute lymphoblastic leukaemia in young adulthood ( 29296818) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 25855136 27539887) Benign prostatic hyperplasia and/or lower urinary tract symptoms ( 28656603) Calcium levels ( 24068962) Colorectal cancer ( 25990418 30529582 28869801 24737748) Colorectal cancer (diet interaction) ( 24743840) Colorectal cancer or advanced adenoma ( 30510241) Craniofacial microsomia ( 26853712) Eosinophil counts ( 27863252) Fasting glucose change (short-term) ( 31263163) General risk tolerance (MTAG) ( 30643258) Glycemic traits (pleiotropy) ( 31021400) Hair shape ( 29220522) Hodgkin's lymphoma ( 21037568 29196614 24920014) Intracranial aneurysm ( 29531279) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244) Nasal polyps ( 30643255) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obstetric antiphospholipid syndrome ( 28424481) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Plasma parathyroid hormone levels ( 30134803) Recalcitrant atopic dermatitis ( 25935106) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Scalp hair shape ( 26926045) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Smoking status (ever vs never smokers) ( 30643258) Stroke ( 26089329) Systemic lupus erythematosus ( 26502338) Takayasu arteritis ( 25604533) Thyroid stimulating hormone levels ( 30367059) Type 1 diabetes ( 31152121)
Interacting Genes		11 interacting genes: CTBP1 CTBP2 E2F6 EP300 GATA1 GATA3 GATA4 IL32 ITSN1 STAT3 UBQLN4	22 interacting genes: ACTN2 CDK2 ETS1 ETS2 FBXW7 HDAC1 HDAC2 HDAC3 HIF1A LCK LMO1 LMO2 MAPK14 MED1 PSMA3 RARB REPIN1 SATB1 SP1 SPI1 TAL1 ZFPM2
Entrez ID		23414	2625
HPRD ID		04737	00572
Ensembl ID		ENSG00000169946	ENSG00000107485
Uniprot IDs		Q8WW38 Q9NPQ0	P23771
PDB IDs			4HC7 4HC9 4HCA
Enriched GO Terms of Interacting Partners?
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