EXOSC2 and MRPL48

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		EXOSC2	MRPL48
Description		exosome component 2	mitochondrial ribosomal protein L48
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding	Protein Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS			Dimensional psychopathology (Cognitive) ( 29496196) Major depressive disorder ( 29317602) Obesity-related traits ( 23251661)
Interacting Genes		27 interacting genes: ADAMTS13 AMBP ANGPTL2 CACFD1 COLEC12 DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FBXW2 GALNT13 KHSRP KIFBP MPP6 MRPL48 MTREX MTX2 NCS1 NELFB RNF8 ST6GALNAC1 UPF1 VCAM1 ZNF408	4 interacting genes: APP EXOSC2 LSM8 OXA1L
Entrez ID		23404	51642
HPRD ID		03758	14767
Ensembl ID		ENSG00000130713	ENSG00000175581
Uniprot IDs		B3KQW2 Q13868	F5H8D0 Q96GC5
PDB IDs		2NN6 6D6Q 6D6R 6H25	3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
Enriched GO Terms of Interacting Partners?
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