CRTC1 and PLAT

		CRTC1	PLAT
Description		CREB regulated transcription coactivator 1	plasminogen activator, tissue type
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Nuclear Body Dendrite Neuronal Cell Body Glutamatergic Synapse	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding CAMP Response Element Binding Protein Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding
	Biological Process	Memory Viral Process Positive Regulation Of CREB Transcription Factor Activity Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Homotetramerization Energy Homeostasis Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Dendrite Development Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Membrane Hyperpolarization	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock Circadian Clock	Signaling by PDGF Dissolution of Fibrin Clot
Drugs			Urokinase Aminocaproic Acid Ibuprofen Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Body fat percentage ( 26833246) Body mass index ( 28552196 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Estimated glomerular filtration rate ( 31152163) Gastroesophageal reflux disease ( 31527586) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Menarche (age at onset) ( 21102462 25231870)	Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)
Interacting Genes		5 interacting genes: CREB1 MAP3K1 PLAT SRPK2 YWHAG	36 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC
Entrez ID		23373	5327
HPRD ID		06339	01419
Ensembl ID		ENSG00000105662	ENSG00000104368
Uniprot IDs		Q6UUV9	B4DN26 P00750
PDB IDs			1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?
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