OBSL1 and KCNE4

Number of citations of the paper that reports this interaction (PubMedID 20498229)
13

Data Source:
BioGRID (two hybrid)

		OBSL1	KCNE4
Description		obscurin like cytoskeletal adaptor 1	potassium voltage-gated channel subfamily E regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Intercalated Disc Z Disc M Band Perinuclear Region Of Cytoplasm 3M Complex	Voltage-gated Potassium Channel Complex Apical Plasma Membrane
	Molecular Function	Protein Binding Cytoskeletal Adaptor Activity	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Microtubule Cytoskeleton Organization Cytoskeleton Organization Golgi Organization Regulation Of Mitotic Nuclear Division Protein Localization To Golgi Apparatus Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis Cardiac Myofibril Assembly	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Neddylation	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs
Diseases		3M syndrome
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Logical memory (delayed recall) in normal cognition ( 29274321) Mean platelet volume ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		4 interacting genes: HSPB1 KCNE4 MCPH1 TNS2	7 interacting genes: FLNA KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TSNAX
Entrez ID		23363	23704
HPRD ID		19306	09689
Ensembl ID		ENSG00000124006	ENSG00000152049
Uniprot IDs		O75147 Q9H8B3	A5H1P5 Q8WWG9
PDB IDs		2CPC 2E6P 2E6Q 2LU7 2LVC 2WP3 2WWK 2WWM 3KNB 5FM5
Enriched GO Terms of Interacting Partners?
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