FN1 and FASLG

Number of citations of the paper that reports this interaction (PubMedID 11276204)
18

Data Source:
HPRD (in vivo, in vitro)

		FN1	FASLG
Description		fibronectin 1	Fas ligand
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cell Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Protease Binding Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Protein C-terminus Binding Heparin Binding Peptidase Activator Activity Enzyme Binding Identical Protein Binding Proteoglycan Binding Chaperone Binding Disordered Domain Specific Binding	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Angiogenesis Regulation Of Protein Phosphorylation Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Peptide Cross-linking Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Wound Healing Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Axon Extension Positive Regulation Of Fibroblast Proliferation Leukocyte Migration Interaction With Symbiont Regulation Of ERK1 And ERK2 Cascade Neural Crest Cell Migration Involved In Autonomic Nervous System Development Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Transforming Growth Factor-beta Secretion	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Cellular Response To Interferon-gamma Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Platelet degranulation Degradation of the extracellular matrix Degradation of the extracellular matrix Extracellular matrix organization Fibronectin matrix formation Cell surface interactions at the vascular wall Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Interleukin-4 and Interleukin-13 signaling Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates PTK2 signaling Post-translational protein phosphorylation Signaling downstream of RAS mutants	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Interleukin-4 and Interleukin-13 signaling Dimerization of procaspase-8 FasL/ CD95L signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO-mediated transcription of cell death genes TNFs bind their physiological receptors
Drugs		Zinc Ocriplasmin
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Blood protein levels ( 30072576 28240269) Cholesterol, total ( 26780889) Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 30578418) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Negative urgency ( 30718321) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878 30578418) Total cholesterol levels ( 28334899)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 22057235 20190752 25920553 24999842) Crohn's disease ( 21102463 23128233) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Psoriasis ( 28537254) Systemic lupus erythematosus ( 28714469) Vitiligo ( 27723757)
Interacting Genes		103 interacting genes: ADAMTS4 AMBP ANOS1 APCS ATXN10 ATXN7 C1QA CCN3 CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA2B ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MTDH MTNR1A MYOC NPTX1 NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TIMD4 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VEGFA VHL	74 interacting genes: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB1 FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NLA OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1
Entrez ID		2335	356
HPRD ID		00626	00610
Ensembl ID		ENSG00000115414	ENSG00000117560
Uniprot IDs		B7ZLE5 P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6	P48023 Q53ZZ1
PDB IDs		1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2MNU 2N1K 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG 4LXO 4MMX 4MMY 4MMZ 4PZ5 5DC0 5DC4 5DC9 5DFT 5J6Z 5J7C 5M0A 5N47 5N48 6HNF 6MFA 6MSV	1BZI 4MSV 5L19 5L36
Enriched GO Terms of Interacting Partners?
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