SYNE1 and DTNBP1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		SYNE1	DTNBP1
Description		spectrin repeat containing nuclear envelope protein 1	dystrobrevin binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cell Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Sarcoplasm Cell Junction Axon Growth Cone Midbody Synaptic Vesicle Membrane BLOC-1 Complex Melanosome Membrane Sarcolemma Neuron Projection Dendritic Spine Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Protein Homodimerization Activity Actin Filament Binding	Protein Binding
	Biological Process	Nucleus Organization Golgi Organization Spermatogenesis Muscle Cell Differentiation Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane	Positive Regulation Of Neurotransmitter Secretion Blood Coagulation Anterograde Axonal Transport Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Neuron Projection Development Actin Cytoskeleton Reorganization Negative Regulation Of Protein Binding Melanosome Organization Regulation Of JUN Kinase Activity Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis
Pathways		Meiotic synapsis	Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Emery-Dreifuss muscular dystrophy Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Hermansky-Pudlak syndrome (HPS)
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 28115744 21926972 31043756 28072414 20351715 21738484) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Heel bone mineral density ( 30598549 28869591) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 31249589 30194396 31649266)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Multiple myeloma ( 27363682) Squamous cell carcinoma ( 31174203)
Interacting Genes		18 interacting genes: ACTC1 APC CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 ECPAS EMD LINC00839 LMNA MTDH MUSK NDEL1 SH3BP5 TNIK USP21	46 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S5 BLOC1S6 BRF1 CCDC146 CCDC153 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DST DTNA DTNB ELOVL7 HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 MACF1 NBEA NDN NUF2 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TRAF3IP1 TRIM2 TRIM27 TRIM9 WASHC3 ZNF490
Entrez ID		23345	84062
HPRD ID		09762	06190
Ensembl ID		ENSG00000131018	ENSG00000047579
Uniprot IDs		A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91	A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8
PDB IDs		4DXR
Enriched GO Terms of Interacting Partners?
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