VPS39 and RTF1

		VPS39	RTF1
Description		VPS39 subunit of HOPS complex	RTF1 homolog, Paf1/RNA polymerase II complex component
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane AP-3 Adaptor Complex HOPS Complex Late Endosome Membrane	Nucleoplasm Nucleolus Cdc73/Paf1 Complex
	Molecular Function		Single-stranded DNA Binding RNA Binding Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	Intracellular Protein Transport Autophagy Endosome To Lysosome Transport Vesicle-mediated Transport Endosomal Vesicle Fusion Late Endosome To Lysosome Transport Retrograde Transport, Endosome To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Blastocyst Growth Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation
Pathways			Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Coronary artery disease ( 29212778) Eosinophil percentage of granulocytes ( 27863252) Height ( 20881960) Itch intensity from mosquito bite ( 28199695) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: HOOK1 NUSAP1 OIP5 RAB7A RILP RTF1 SNW1 STAT3	4 interacting genes: APP SRPK2 TCEA1 VPS39
Entrez ID		23339	23168
HPRD ID		10300	11071
Ensembl ID		ENSG00000166887	ENSG00000137815
Uniprot IDs		A0A024R9L9 Q96JC1	Q92541
PDB IDs			2BZE 2DB9 3U1U 4L1P 4L1U
Enriched GO Terms of Interacting Partners?
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