SYNM and DES

Number of citations of the paper that reports this interaction (PubMedID 11353857)
32

Data Source:
HPRD (in vitro)

		SYNM	DES
Description		synemin	desmin
Image			No pdb structure
GO Annotations	Cellular Component	Intermediate Filament Adherens Junction Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton	Nucleus Cytosol Intermediate Filament Fascia Adherens Intercalated Disc Z Disc Neuromuscular Junction Sarcolemma Intermediate Filament Cytoskeleton Extracellular Exosome Cardiac Myofibril
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Intermediate Filament Organization
Pathways			Striated Muscle Contraction
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)	Resting heart rate ( 27798624)
Interacting Genes		4 interacting genes: DES DTNA PCSK6 SELENOS	27 interacting genes: AURKB BRCA1 CAPN1 CRYAB DDX10 DSP EHHADH HSPB1 ITSN1 MAPKAPK2 NEB NEFL PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I VIM
Entrez ID		23336	1674
HPRD ID		07305	00514
Ensembl ID		ENSG00000182253	ENSG00000175084
Uniprot IDs		A0A075B7B1 O15061	P17661 Q53SB5
PDB IDs		6EWO
Enriched GO Terms of Interacting Partners?
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