UBR2 and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 22616001)
14

Data Source:
BioGRID (pull down)

		UBR2	UBE2H
Description		ubiquitin protein ligase E3 component n-recognin 2	ubiquitin conjugating enzyme E2 H
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Cytoplasm Cytosol	Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Chromatin Silencing Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Negative Regulation Of Transposition Protein Ubiquitination Negative Regulation Of TOR Signaling Histone H2A Ubiquitination Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lung cancer in never smokers ( 28604730) Obesity-related traits ( 23251661) Serum total protein level ( 29403010)	Estimated glomerular filtration rate ( 31152163 31451708) Response to antidepressants and depression ( 27622933)
Interacting Genes		5 interacting genes: H2AC20 H2BC8 UBE2B UBE2D2 UBE2H	67 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 UBA1 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		23304	7328
HPRD ID		09853	03052
Ensembl ID		ENSG00000024048	ENSG00000186591
Uniprot IDs		B3KXG6 Q8IWV8	A0A3B3IU20 A4D1L5 P62256
PDB IDs		3NY2 3NY3 5TDA 5TDB 5TDD 5UM3	2Z5D
Enriched GO Terms of Interacting Partners?
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