MGA and CBX3

Number of citations of the paper that reports this interaction (PubMedID 20850016)
295

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		MGA	CBX3
Description		MAX dimerization protein MGA	chromobox 3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm MLL1 Complex	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Spindle Nuclear Pericentric Heterochromatin Senescence-associated Heterochromatin Focus Site Of DNA Damage
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G0 To G1 Transition	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus
Pathways		Transcriptional Regulation by E2F6	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Feeling nervous ( 29500382) Lung function (FEV1/FVC) ( 28166213 30804560) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: CBX3 E2F1 E2F3 E2F4 H3-4 LSM8 MAX SMAD1	32 interacting genes: ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 DNMT3B DSN1 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 KLF11 L3MBTL1 LBR MGA MIS12 MKI67 NSD3 NSL1 PIM1 SP100 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF496
Entrez ID		23269	11335
HPRD ID		19055	05130
Ensembl ID		ENSG00000174197	ENSG00000122565
Uniprot IDs		Q8IWI9	A4D177 Q13185
PDB IDs			2L11 3DM1 3KUP 3TZD 5T1I
Enriched GO Terms of Interacting Partners?
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