PMPCA and BMPR2

Number of citations of the paper that reports this interaction (PubMedID 15188402)
31

Data Source:
HPRD (in vitro)

		PMPCA	BMPR2
Description		peptidase, mitochondrial processing subunit alpha	bone morphogenetic protein receptor type 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Mitochondrial Inner Membrane Mitochondrial Processing Peptidase Complex	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Apical Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex Spanning Component Of Plasma Membrane
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Proteolysis Protein Processing Involved In Protein Targeting To Mitochondrion Mitochondrial Calcium Ion Transmembrane Transport	Blood Vessel Development Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Transcription By RNA Polymerase II Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Negative Regulation Of DNA Biosynthetic Process
Pathways		Mitochondrial protein import Processing of SMDT1	Signaling by BMP
Drugs
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 28067908) Granulocyte count ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) White blood cell count ( 27863252)	Intelligence (MTAG) ( 29326435) Medication use (HMG CoA reductase inhibitors) ( 31015401) Urate levels ( 23263486)
Interacting Genes		13 interacting genes: ASS1 AVEN BMPR2 KIF2C NDOR1 NPSR1 NSMF OLFM1 PCDHB4 PMPCB SCUBE1 SKIV2L UBAC1	51 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TDGF1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		23203	659
HPRD ID		07500	02880
Ensembl ID		ENSG00000165688	ENSG00000204217
Uniprot IDs		Q10713	Q13873
PDB IDs			2HLQ 3G2F
Enriched GO Terms of Interacting Partners?
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