FAM168A and OTULIN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FAM168A	OTULIN
Description		family with sequence similarity 168 member A	OTU deubiquitinase with linear linkage specificity
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol LUBAC Complex
	Molecular Function	Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Positive Regulation Of Base-excision Repair	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways			Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30061609) Pulmonary function (smoking interaction) ( 23284291) Waist-hip ratio ( 28552196)	Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)
Interacting Genes		24 interacting genes: C1orf94 CALCOCO2 DAB1 DAZAP2 DTX2 FBXW5 HGS KLHL42 NAF1 OTUB2 OTULIN PRR20A R3HDM2 RBFOX1 RBPMS SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TNIP1 UBASH3B UBE2V1 VPS37C	6 interacting genes: BCL10 DAZAP2 DVL2 FAM168A SPATA2 VCP
Entrez ID		23201	90268
HPRD ID		13792	14266
Ensembl ID		ENSG00000054965	ENSG00000154124
Uniprot IDs		Q92567	Q96BN8
PDB IDs			3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK
Enriched GO Terms of Interacting Partners?
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