TAB2 and EIF2AK2

Number of citations of the paper that reports this interaction (PubMedID 12609980)
80

Data Source:
HPRD (in vivo)

		TAB2	EIF2AK2
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 2	eukaryotic translation initiation factor 2 alpha kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Endosome Membrane	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Regulator Activity Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Heart Development Negative Regulation Of Autophagy Response To Lipopolysaccharide Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Translation Protein Phosphorylation Negative Regulation Of Cell Proliferation Response To Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Evasion Or Tolerance By Virus Of Host Immune Response Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	ISG15 antiviral mechanism Inhibition of PKR
Drugs
Diseases
GWAS		Breast cancer ( 22383897 29059683) Diverticulitis ( 28585551) Dupuytren's disease ( 28886342 21732829)	Glucose homeostasis traits ( 25524916)
Interacting Genes		34 interacting genes: APP CST9L EIF2AK2 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 IKBKB IKBKG IRAK1 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TRAF2 TRAF3IP1 TRAF6 UBC UBE2I VIM XIAP YWHAZ ZBTB16	49 interacting genes: CASP3 CASP7 CASP8 CDC42 CHUK DHX30 DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 STAT1 STAT3 STRBP TAB2 TARBP2 THAP12 TIRAP TOLLIP TP53 TYK2 ZNF346
Entrez ID		23118	5610
HPRD ID		05483	01468
Ensembl ID		ENSG00000055208	ENSG00000055332
Uniprot IDs		B4DIR9 Q9NYJ8	P19525 Q8IW76
PDB IDs		2DAE 2WWZ 2WX0 2WX1	1QU6 2A19 2A1A 3UIU 6D3K 6D3L
Enriched GO Terms of Interacting Partners?
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