KIF1B and ARHGAP1

Number of citations of the paper that reports this interaction (PubMedID 14697242)
21

Data Source:
HPRD (two hybrid)

		KIF1B	ARHGAP1
Description		kinesin family member 1B	Rho GTPase activating protein 1
Image
GO Annotations	Cellular Component	Mitochondrion Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Cell Junction Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Axon Cytoplasm	Cytoplasm Cytosol Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Sorting Endosome
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity Kinesin Binding Kinase Binding Scaffold Protein Binding	SH3/SH2 Adaptor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Rab GTPase Binding Cadherin Binding
	Biological Process	Apoptotic Process Microtubule-based Movement Neuron-neuron Synaptic Transmission Neuromuscular Synaptic Transmission Anterograde Axonal Transport Positive Regulation Of Gene Expression Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Lysosome Localization Mitochondrion Transport Along Microtubule Response To Rotenone Anterograde Neuronal Dense Core Vesicle Transport Retrograde Neuronal Dense Core Vesicle Transport Cellular Response To Nerve Growth Factor Stimulus Protein Localization To Cell Periphery	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Endosomal Transport Transferrin Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Endocytic Recycling
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Rho GTPase cycle
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hepatitis B virus-related hepatocellular carcinoma ( 29246937) Hepatocellular carcinoma ( 20676096) Lateral orbital frontal cortex volume ( 31530798) Mean platelet volume ( 22139419 27863252) Multiple sclerosis ( 18997785) Virologic severity in Herpes simplex virus type 2 infection ( 29535370) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Bone mineral density (hip) ( 19801982) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Femoral neck bone mineral density ( 22504420) Neurociticism ( 29500382) Reaction time ( 29844566) Schizophrenia ( 29483656) Suffering from nerves ( 29500382)
Interacting Genes		16 interacting genes: ARHGAP1 BRCA1 CALM1 CHP1 CPEB1 DLG1 DLG2 DLG3 DLG4 EEF1A1 GIPC1 PATJ SIAH1 SNTA1 STARD13 YWHAG	23 interacting genes: ADGRB2 AGTRAP BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B MTNR1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SMARCD3 SRC TAX1BP1 TUBA4A WAS
Entrez ID		23095	392
HPRD ID		05818	04108
Ensembl ID		ENSG00000054523	ENSG00000175220
Uniprot IDs		O60333	Q07960
PDB IDs		2EH0	1AM4 1GRN 1OW3 1RGP 1TX4 2NGR 5M6X 5M70 6R3V
Enriched GO Terms of Interacting Partners?
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