UNC13A and EPB41L3

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)

		UNC13A	EPB41L3
Description		unc-13 homolog A	erythrocyte membrane protein band 4.1 like 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Junction Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Calyx Of Held Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse	Cell Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Postsynaptic Density Cell Junction Axolemma Paranode Region Of Axon Juxtaparanode Region Of Axon
	Molecular Function	Calcium Ion Binding Calmodulin Binding Phospholipid Binding Syntaxin-1 Binding Diacylglycerol Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Neurotransmitter Secretion Neuromuscular Junction Development Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Maturation Positive Regulation Of Synaptic Plasticity Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Regulation Of Short-term Neuronal Synaptic Plasticity Amyloid-beta Metabolic Process Regulation Of Synaptic Transmission, Glutamatergic Innervation Dense Core Granule Priming Neuronal Dense Core Vesicle Exocytosis Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Dendrite Extension	Regulation Of Cell Growth Protein Localization To Paranode Region Of Axon Apoptotic Process Cytoskeletal Anchoring At Plasma Membrane Biological_process Regulation Of Cell Shape Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Paranodal Junction Assembly Actomyosin Structure Organization Myelin Maintenance Neuron Projection Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane
Pathways			Neurexins and neuroligins
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793 22959728 27455348 19734901 24931836) Amyotrophic lateral sclerosis (sporadic) ( 24256812 28931804) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Benign prostatic hyperplasia ( 30988330) Frontotemporal dementia ( 24931836) IgG levels ( 28628107) Obesity-related traits ( 23251661)	Cerebral amyloid deposition (PET imaging) ( 26252872) Chronic kidney disease ( 31152163) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Glomerular filtration rate (creatinine) ( 28452372) Optic nerve head parameters (multi-trait analysis) ( 31798171) Sleep duration ( 25469926) Social communication problems ( 24564958) Thyroid nodules ( 30099483) Vertical cup-disc ratio ( 31798171)
Interacting Genes		2 interacting genes: EPB41L3 UBXN10	18 interacting genes: ATXN1L CADM1 CEP152 CLNS1A CNTNAP2 HSPB1 IGSF21 MBIP PAXIP1 PSEN1 SPTBN1 TCF4 UNC13A YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		23025	23136
HPRD ID		19058	05622
Ensembl ID		ENSG00000130477	ENSG00000082397
Uniprot IDs		Q9UPW8	A0A0A0MRA8 A8K968 Q9Y2J2
PDB IDs			2HE7 3BIN 6IBE
Enriched GO Terms of Interacting Partners?
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