SPEN and MBD3

Number of citations of the paper that reports this interaction (PubMedID 11331609)
115

Data Source:
HPRD (in vivo)

		SPEN	MBD3
Description		spen family transcriptional repressor	methyl-CpG binding domain protein 3
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GO Annotations	Cellular Component	Nucleoplasm Transcriptional Repressor Complex Extracellular Exosome	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurogenesis	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Erectile dysfunction ( 30583798) Heel bone mineral density ( 28869591)
Interacting Genes		22 interacting genes: ATXN1 CLK1 CTBP1 DLX5 HDAC1 HDAC2 MBD3 MSX2 MTA2 NCOR1 NCOR2 PPARD RARA RBBP4 RBPJ RIDA RUNX1 RUNX1T1 SERTAD1 SOX9 SRPK2 UBE2L6	29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277
Entrez ID		23013	53615
HPRD ID		10230	04653
Ensembl ID		ENSG00000065526	ENSG00000071655
Uniprot IDs		Q96T58	O95983
PDB IDs		1OW1 2RT5 4P6Q	2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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