SIRT2 and CDC14B

Number of citations of the paper that reports this interaction (PubMedID 12697818)
152

Data Source:
HPRD (in vivo, in vitro)

		SIRT2	CDC14B
Description		sirtuin 2	cell division cycle 14B
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromatin Silencing Complex Chromosome Nuclear Heterochromatin Nucleolus Cytoplasm Mitochondrion Centrosome Centriole Spindle Cytosol Microtubule Plasma Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Mitotic Spindle
	Molecular Function	Chromatin Binding NAD+ ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Protein Deacetylase Activity NAD-dependent Protein Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD+ Binding	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing At RDNA Chromatin Silencing Chromatin Silencing At Telomere Protein ADP-ribosylation Protein Deacetylation Autophagy Regulation Of Exit From Mitosis Negative Regulation Of Cell Proliferation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Phosphatidylinositol 3-kinase Signaling Histone Deacetylation Substantia Nigra Development Myelination In Peripheral Nervous System Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Protein Kinase B Signaling Cellular Lipid Catabolic Process Innate Immune Response Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Caloric Restriction Negative Regulation Of Oligodendrocyte Progenitor Proliferation Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Molecule Of Bacterial Origin Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response To Bacterium Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	Microtubule Cytoskeleton Organization Mitotic Cell Cycle DNA Repair Protein Dephosphorylation Regulation Of Exit From Mitosis G2 DNA Damage Checkpoint Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Cilium Assembly Mitotic Cell Cycle Arrest Signal Transduction Involved In G2 DNA Damage Checkpoint Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Initiation of Nuclear Envelope (NE) Reformation	MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS			Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Height ( 31562340) Household income ( 31844048) Intelligence (MTAG) ( 29326435) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		18 interacting genes: ARHGDIA CDC14B CDC20 CDK2 EP300 FZR1 H3C1 HDAC6 HIF1A HOXA10 KAT2A KAT2B MDM2 PLA2G4A RAD51 SP140 TUBA4A XPO1	5 interacting genes: MTDH MYCBP2 SIRT2 SKP2 TP53
Entrez ID		22933	8555
HPRD ID		10377	04615
Ensembl ID		ENSG00000068903	ENSG00000081377
Uniprot IDs		A0A024R0G8 A0A0A0MRF5 Q8IXJ6	O60729
PDB IDs		1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y0Z 5Y5N 5YQL 5YQM 5YQN 5YQO	1OHC 1OHD 1OHE
Enriched GO Terms of Interacting Partners?
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