RAB3GAP1 and WDR7

Number of citations of the paper that reports this interaction (PubMedID 12786944)
18

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAB3GAP1	WDR7
Description		RAB3 GTPase activating protein catalytic subunit 1	WD repeat domain 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Protein-containing Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Postsynapse	Synaptic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Brain Development Positive Regulation Of Gene Expression Hypothalamus Development Lipid Droplet Organization Camera-type Eye Development Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Short-term Neuronal Synaptic Plasticity Excitatory Postsynaptic Potential Face Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Autophagosome Assembly	Hematopoietic Progenitor Cell Differentiation
Pathways		COPI-independent Golgi-to-ER retrograde traffic RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Warburg micro syndrome Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Blood metabolite levels ( 24816252) Body mass index ( 25673413) Cholesterol, total ( 24097068 25961943 20686565) Corneal structure ( 21979947) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Depression and alcohol dependence ( 22064162) Multiple sclerosis (age of onset) ( 19010793) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 30297969)
Interacting Genes		8 interacting genes: FEZ1 FEZ2 RAB22A RAB39A RAB39B RAB3GAP2 RPH3AL WDR7	2 interacting genes: FRMD6 RAB3GAP1
Entrez ID		22930	23335
HPRD ID		16002	10306
Ensembl ID		ENSG00000115839	ENSG00000091157
Uniprot IDs		B9A6J2 Q15042	Q9Y4E6
PDB IDs
Enriched GO Terms of Interacting Partners?
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