NLGN1 and DLG3

Number of citations of the paper that reports this interaction (PubMedID 9278515)
202

Data Source:
BioGRID (two hybrid)

		NLGN1	DLG3
Description		neuroligin 1	discs large MAGUK scaffold protein 3
Image
GO Annotations	Cellular Component	Cell Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Filopodium Tip Synaptic Cleft Dendritic Spine Dendritic Shaft Receptor Complex Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Postsynapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Extracellular Space Cytosol Plasma Membrane Bicellular Tight Junction Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction Growth Cone AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Shaft Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Amyloid-beta Binding PDZ Domain Binding Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Protein Binding Protein C-terminus Binding Kinase Binding Phosphatase Binding Protein Phosphatase Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Chemical Synaptic Transmission Nervous System Development Synapse Assembly Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Cytoskeletal Matrix Organization At Active Zone Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Neurexin Clustering Involved In Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Postsynaptic Specialization Assembly Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Presynapse Assembly Synaptic Membrane Adhesion Neuron Projection Arborization Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Localization To Synapse Positive Regulation Of Intracellular Signal Transduction Excitatory Synapse Assembly Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering	MAPK Cascade Establishment Of Planar Polarity Negative Regulation Of Cell Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure Regulation Of NMDA Receptor Activity
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Adventurousness ( 30643258) Adverse response to drug ( 30420678) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Hand grip strength ( 29691431) Major depressive disorder ( 20516156) Metabolite levels ( 23823483) Motion sickness ( 25628336) Periodontitis (DPAL) ( 24024966) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)
Interacting Genes		6 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3	40 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 PTK2B SCN4A SCN5A SEMA4C SYNGAP1
Entrez ID		22871	1741
HPRD ID		07195	02177
Ensembl ID		ENSG00000169760	ENSG00000082458
Uniprot IDs		Q8N2Q7	Q59FY1 Q92796
PDB IDs		5OJ6 5OJK	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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